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Analysis of Post-Translational Modifications and Proteolysis in Neuroscience

Analysis of Post-Translational Modifications and Proteolysis in Neuroscience ab 149.99 € als gebundene Ausgabe: 1st ed. 2016. Aus dem Bereich: Bücher, Wissenschaft, Medizin,

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Price: 149.99 EUR excl. shipping

Analysis of Post-Translational Modifications and Proteolysis in Neuroscience

Analysis of Post-Translational Modifications and Proteolysis in Neuroscience ab 106.99 € als Taschenbuch: Softcover reprint of the original 1st ed. 2016. Aus dem Bereich: Bücher, Taschenbücher, Naturwissenschaft,

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Price: 106.99 EUR excl. shipping

Lung Metabolism

Lung Metabolism ab 54.99 € als pdf eBook: Proteolysis and Antioproteolysis Biochemical Pharmacology Handling of Bioactive Substances. Aus dem Bereich: eBooks, Fachthemen & Wissenschaft, Medizin,

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Cell Cycle Regulation and Development in Alphaproteobacteria (eBook, PDF)

This book provides a comprehensive overview of the cell cycle regulation and development in Alphaproteobacteria. Cell cycle and cellular differentiation are fascinating biological phenomena that are highly regulated in all organisms. In the last decades, many laboratories around the world have been investigating these processes in Alphaproteobacteria. This bacterial class comprises important bacterial species, studied by fundamental and applied research. The complexity of cell cycle regulation and many examples of cellular differentiations in this bacterial group represent the main motives of this book. The book starts with discussing the regulation of cell cycle in alphaproteobacterial species from a system biology perspective. The following chapters specifically focus on the model species Caulobacter crescentus multiple layers of regulation, from transcriptional cascades to proteolysis and dynamic subcellular regulation of cell cycle regulators. In addition, the cell division process, chromosome segregation and growth of the cell envelope is described in detail. The last part of the book covers examples of non-Caulobacter alphaproteobacterial models, such as Agrobacterium tumefaciens, Brucella species and Sinorhizobium meliloti and also discusses possible applications. This book will be of interest to researchers in microbiology and cell biology labs working on cell cycle regulation and development.

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Price: 121.95 EUR excl. shipping

Contemporary Accounts in Drug Discovery and Development

CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENTA useful guide for medicinal chemists and pharmaceutical scientistsDrug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners' knowledge of chemistry and biology, but also--and perhaps more importantly--on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field.Contemporary Accounts in Drug Discovery and Development provides drug discovery scientists with the knowledge they need to quickly gain mastery of the drug discovery process. A thorough accounting is given for each drug covered within the book, as the authors provide pharmacology, drug metabolism, biology, drug development, and clinical studies for every case, with modern drug discovery principles and technologies incorporated throughout.Contemporary Accounts in Drug Discovery and Development readers will also find* Case histories used as an engaging way of learning about the drug discovery/development process* Detailed biological rational and background information, drug design principles, SAR development, ADMET considerations, and clinical studies* The full history of individual marketed small molecule drugs* Coverage of drug candidates that have passed Phase I clinical trials with different modalities, such as antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC), and peptide drugs* The application of new technologies in drug discovery such as DNA-encoded libraries (DEL), positron emission tomography (PET), and physics-based computational modeling employing free energy perturbation (FEP)Contemporary Accounts in Drug Discovery and Development is a helpful tool for medicinal chemists, organic chemists, pharmacologists, and other scientists in drug research and process development. It may be considered essential reading for graduate courses in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical science, and pharmacology. It is also a useful resource for pharmaceutical industry labs, as well as for libraries.

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Price: 194.99 EUR excl. shipping